The Sacrificator of better known today as a vaccine. Back then they dipped 4 blades into the pustule of a child who was already infected, stabbed the blades into their arm, and have them a band aid if the didn't cry.
Trephine This trephine was a hand-powered drill with a cylindrical blade that was used to bore into the skull. The spike in the center was used to start the procedure and to hold the blade in place while cutting. Looks like a corkscrew.